Research‑Grade mRNA That Moves as Fast as Your Ideas
Learn more about key considerations when sourcing research-grade mRNA and discover Vernal’s approach to its new research-grade mRNA manufacturing service offering.
Unlocking Oral RNA Therapeutics: Overcoming Barriers to Gut-Stable Gene Delivery
Oral delivery of RNA therapeutics has long been viewed as a scientific improbability due to the instability of RNA and the hostile environment of the gastrointestinal tract. But recent innovations in lipid nanoparticles, polymeric carriers, extracellular vesicles, and even microneedle-based ingestible devices are rapidly reshaping what’s possible.
Source: Pharma’s Almanac, David Alvaro, Ph.D, July 18, 2025, PAO-07-25-NI-08
Less Pain, More Gain: A New Recipe for Safer, Stronger mRNA Therapies
Researchers at the University of Pennsylvania have demonstrated that modifying the structure of the ionizable lipid, a crucial component of lipid nanoparticles (LNPs) that deliver mRNA, not only reduces inflammation but also enhances vaccine effectiveness for preventing or treating a range of diseases, including COVID-19 and cancer.
Source: University of Pennsylvania School of Engineering and Applied Science, July 18, 2025, Author: Ian Scheffler. Image showing Bioengineering researchers Emily Han and Dongyoon Kim, from left. (Credit: Bella Ciervo)
Efficacy Versus Immunogenicity of LNP-Mediated Delivery of mRNA and Self-Amplifying RNA Upon Intravitreal Injection in the Mouse Eye
By delivering carefully designed mRNAs, it is possible to restore, replace, or modulate gene function, opening new avenues for regenerative therapies and vision preservation.
Source: ScienceDirect, Journal of Controlled Release, Volume 385, 10 September 2025, 114027
Virus-Like Particles Enhance Effect of mRNA Vaccine
In a new study, scientists from the University of Copenhagen and the biotech company AdaptVac show that mice develop a stronger and longer-lasting immune response when the mRNA vaccine is disguised as virus-like particles.
Source: Drug Discovery World, Diana Spencer, Senior Digital Content Editor, June 24, 2025, Image Credit: Drug Discovery World, June 24, 2025
Surprising Finding Could Pave Way for Universal Cancer Vaccine
An experimental mRNA vaccine boosted the tumor-fighting effects of immunotherapy in a mouse-model study, bringing researchers one step closer to their goal of developing a universal vaccine to “wake up” the immune system against cancer.
Source: UFHealth, July 18, 2025, Michelle Jaffee, Image Credit: ufhealth.org – A University of Florida research team led by Elias Sayour, M.D., Ph.D., (center) developed an mRNA vaccine that boosted the tumor-fighting effects of immunotherapy in a mouse-model study.