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Building an mRNA Manufacturing Ecosytem in Vermont

Hot tip: When building a GMP facility, make sure to have proper ventilation for your clean room

Located in beautiful Vermont, Vernal Biosciences’ mRNA Center of Excellence at Colchester has been manufacturing high quality mRNA and LNP products for mRNA clients since 2021, fast tracking their drug discovery and research. To support the advancement of our clients’ preclinical and clinical programs, Vernal is taking a stage-gated approach to offer GMP mRNA and LNP production services as early as mid 2023.  The upgraded manufacturing space will house a GMP production suite, QC lab, warehouse, and additional lab and office space in a total building area of 23,000 square feet.  Their clean rooms will be open for business in July of 2023.

Vernal Biosciences is also advancing a brand new 20,000 square foot GMP mRNA manufacturing plant in nearby Essex with even larger manufacturing scale in mind, supporting all use cases of mRNA for later phases of clinical trials. This expansion includes multiple GMP production suites with sterile fill finish capabilities to support clinical and commercial manufacturing for both mRNA and LNP-mRNA. With the “One-Stop Shop” concept in mind, the Essex facility is designed with fully independent process rooms, integrating all the major unit operations, including master cell bank, plasmid DNA, mRNA, LNP formulation, and fill finish to enable manufacturing of critical raw materials, drug substances and drug products all from one single vendor.

Vernal is now booking GMP production slots for clinical-stage clients to kickoff before the end of Q2, 2023.

Current progress of the GMP clean room construction

The upcoming MSAT lab

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