Vernal is an industry leader in providing high quality mRNAs for research and clinical applications.
Vernal’s mRNAs are highly pure mRNAs that incorporate modified nucleoside (N1-methylpseudoUridine), Cap-1 structure, optimized codons and poly(A) tail to improve translation efficiency and reduce host cell immune response. Vernal’s mRNAs function as mature, fully processed mRNAs, and are ready for use in cells and animals.
Reporter Gene mRNA
Vernal offers in stock reporter mRNAs for your project needs. Vernal’s reporter mRNAs function as mature, fully processed mRNAs, useful for analysis of translation efficiency, gene expression, mRNA delivery and biodistribution.
eGFP mRNA
Molecular model of the GFP.
eGFP mRNA VRN-EGFP
Vernal now offers catalog eGFP mRNA that has been optimized to produce high expression level of the enhanced green fluorescent protein. Originally isolated from the jellyfish, Aequorea victoria, eGFP is a powerful reporter molecule broadly utilized for monitoring gene expression and protein localization. eGFP displays bright green fluorescence when exposed to light in the blue to ultraviolet range, with an emissions peak at 509nm. Vernal’s eGFP mRNA is ready to use for a wide variety of functional studies including biodistribution (in vivo imaging), gene regulation, cell viability, and translation efficiency.
Molecular model of the RFP. Computer model shows the DsRed, from which mCherry is derived.
mCherry mRNA VRN-CHER
Vernal now offers catalog mCherry mRNA that has been optimized to produce high expression level of the red fluorescent protein. mCherry was derived from DsRed, a protein originally isolated from Discosoma sea anemones. mCherry is a monomeric fluorophore with a peak absorption maximum at 587nm and emission maximum at 610nm. A robust protein (pH-resistant, high photostability), mCherry is widely used as a reliable fluorescent reporter of gene expression.
Molecular model of the bioluminescent enzyme FLuc complexed with an
intermediate protein.
Firefly Luciferase (FLuc) mRNA VRN-FLUC
Vernal now offers catalog firefly luciferase (FLuc) mRNA that has been optimized to produce high expression level of luciferase enzyme. Originally isolated from the firefly, Photinus pyralis, luciferase catalyzes the oxidation of luciferin, (O2 & ATP dependent), leading to chemiluminescence at 550nm-570nm. FLuc can be utilized for a wide variety of functional studies including biodistribution (in vivo imaging), gene regulation, cell viability and translation efficiency.
Vernal offers in stock gene editing mRNA for your project needs. Vernal’s gene editing mRNAs function as mature, fully processed mRNAs.
Cre Recombinase mRNA
Molecular model of the enzyme Cre recombinase (purple) mediating the
recombination of strands of DNA (pink and green).
Cre Recombinase mRNA VRN-CRE
Vernal now offers catalog Cre recombinase (Cre) mRNA that has been optimized to produce high expression level of the type I topoisomerase from bacteriophage P1. Cre recombinase catalyzes recombination between two loxP sites and is commonly used to precisely control location and timing of gene expression. Due to its cell-specific targeting by allowing genes to be conditionally controlled at specific sites in DNA, the Cre/loxP gene editing system is a powerful tool to study gene functions in animal models.
Vernal offers in stock gene replacement mRNA for your project needs. Vernal’s gene replacement mRNA function as mature, fully processed mRNA, useful for analysis of gene expression and as a gene replacement model.
hEPO mRNA
Molecular model of EPO (blue) bound to two extracellular EPO receptors (green and
purple).
hEPO mRNA VRN-EPO
Vernal now offers catalog hEPO mRNA that has been optimized to produce high expression level of human erythropoietin, a hormone that controls red blood cell production and maturation (erythropoiesis). Naturally produced in the kidneys in response to hypoxia, EPO also plays a role in wound healing and displays neuroprotective effects in response to brain injuries. hEPO mRNA is a common choice of mRNA to test therapeutic potential of different LNP designs for protein replacement therapy to treat diseases including anemia, neurological, and hepatic diseases.
Vernal offers in stock antigen mRNA for your project needs. Vernal’s antigen mRNA function as mature, fully processed mRNA, used to induce a strong immune response, ready for use in cells and animals.
OVA mRNA
Molecular model of the egg white protein.
OVA mRNA VRN-OVA
Vernal now offers catalog Ovalbumin (OVA) mRNA that has been optimized to produce high expression level of glycoprotein, the predominant protein found in egg whites (54%). One of the most extensive and best characterized antigens, OVA is often used as a model antigen in experimental vaccine delivery systems, while its mRNA serves a variety of use cases as an immunogen for immunology research and inflammation studies.
RNA tailored to your program needs. Custom RNA synthesis for your gene of interest using Vernal’s design tool. A team member will assess feasibility and contact you with a quote within 1-2 business days.
