Advancements in Biopharma Spur Innovation
Christian Cobaugh, chief scientific officer and founder of Vernal Biosciences, offered PharmaTech editor Susan Haigney comments about where he believes mRNA and LNP advancements fit into the biopharm innovation landscape.
Source: Pharmaceutical Technology, June 2025, Volume 49, Issue 5, Pages: 12-15
Well-Defined mRNA Platform Processes & Collaboration Advanced a Novel Gene Therapy in Jeopardy
Learn how Vernal Bio changed the course of a stalled cancer gene therapy program, pairing proven mRNA platform methods with scientific flexibility and hands-on collaboration.
The Advent of Clinical Self-Amplifying RNA Vaccines
By enabling intracellular amplification of RNA, self-amplifying RNA (saRNA) facilitates robust antigen expression at lower doses, enhancing immunogenicity and cost-effectiveness.
Source: Molecular Therapy, Volume 33, Issue 6, 4 June 2025, Pages 2565-2582
Data Over Doubt—The Scientific Case for mRNA in Cancer Care
mRNA-based therapies—through reprogramming myeloid cells and enabling in vivo CAR approaches—offer promise for faster, safer, and more affordable solutions for solid tumors. He emphasizes the criticality of data-reliant approaches, urging science‑driven oncology.
Source: Genetic Engineering & Biotechnology News, Daniel Getts, PhD, June 6, 2025
mRNA-LNPs Induce Immune Activation and Cytokine Release in Human Whole Blood Assays Across Diverse Health Conditions
Understanding the immunomodulatory effects of novel mRNA-LNPs is crucial for future therapeutic development. An in vitro whole blood assay was developed to assess the impact of mRNA-LNPs on immune cell function, cytokine release, and complement activation. mRNA-LNPs significantly increased CD69 expression on T cells and natural killer cells, and CD80/CD86 on myeloid subsets, in a dose-dependent fashion.
Source: Molecular Therapy, Volume 33, Issue 6, p2872-2885, June 04, 2025
A Simpler Process for mRNA Purification
Scientists from MIT say they have developed a more straightforward process for messenger RNA (mRNA) purification based on continuous precipitation.
Source: Genetic Engineering and Biotechnology News, Vivienne Raper PhD, June 4, 2025 Credit: Genetic Engineering and Biotechnology News (Kitsawet Saethao/Getty Images)