Vernal now offers catalog Cre recombinase (Cre) mRNA that has been optimized to produce high expression level of the type I topoisomerase from bacteriophage P1. Cre recombinase catalyzes recombination between two loxP sites and is commonly used to precisely control location and timing of gene expression. Due to its cell-specific targeting by allowing genes to be conditionally controlled at specific sites in DNA, the Cre/loxP gene editing system is a powerful tool to study gene functions in animal models.
Vernal’s mRNAs are highly pure mRNAs that incorporate modified nucleoside (N1-methyl-pseudouridine), Cap-1 structure, optimized codons and poly(A) tail to improve translation efficiency and reduce host cell immune response. Vernal’s mRNAs function as mature, fully processed mRNAs, and are ready for use in cells and animals.