Position Summary
The ideal lipid nanoparticle (LNP) Scientist is a quick learner with strong LNP and formulation manufacturing-process sciences experience, and communication skills. The LNP scientist will work to optimize and scale processes to encapsulate RNA using novel ionizable lipids, develop and execute analytical methods to determine the quality of LNP-RNA formulations. The Scientist will directly support MSAT and help with client manufacturing proposals, quality investigations (CAPAs), and manufacturing innovation initiatives. Additionally, the LNP scientist will assist in designing and performing cell-based potency assays for LNP application testing among other analytic methods (HPLC-CAD, Ribogreen, DLS, Endotoxin).
Responsibilities
- Initiate, develop, and tech transfer client-specific GMP project work orders
- Develop, optimize, analyze, and scale LNP-RNA formulations
- Design, execute, and review process initiatives and experiments
- Plan and track usage of critical reagents and supplies
- Maintain cell lines and develop cell-based assays
- Operate as a key player in cutting-edge formulation research
- Report on project status and product critical quality attributes (CQAs)
- Present on major findings and innovation initiatives
- Enjoy the benefits of living in Vermont
Desired skills and background
Vernal is seeking a highly motivated LNP Scientist with strong leadership and communication skills. Our ideal candidate will have a Ph.D. in Engineering, Chemistry or Pharmaceutical Sciences with 5 years of industry experience, or M.S./B.S. in Engineering, Chemistry or Pharmaceutical Sciences experience. If you describe yourself as a great team player who wants to help drive curative therapies to the clinic and
beyond, we encourage you to apply! Other desired skills include:
- Experience designing, executing, and analyzing particle-based drug delivery systems
- Experience directing other scientists and research staff to perform fast paced work and high visibility deliverables
- Preference will be given to candidates with LNP-mRNA formulation, and frozen and lyophilization formulation experience
- Proficiency with a broad spectrum of analytical techniques applicable to nucleic acid drug delivery systems (i.e. particle size, fluorescent assays, HPLC/UPLC, etc)
- Demonstrates creativity and problem-solving skills
- Ability to work independently, as well as part of a team
- Organized, detail-oriented, and a self-starter who continuously seeks to improve existing laboratory methods and processes
- Effective verbal and written communication skills
How to Apply
If you feel that you are a great match for this position and want to make a difference in the exciting field of next-generation therapeutics, then reach out to us at [email protected] and be sure to include your resume and cover letter. We look forward to hearing from you!
Diversity/Equal Opportunity
Vernal is an equal opportunity employer. We recognize the value of diverse, multifaceted approaches towards innovation and aim to incorporate diverse perspectives and experiences. We strive to build a safe, welcoming, and inclusive work culture.
At Vernal, you will offer knowledge-based solutions to help us address the growing demand for mRNA, lipid nanoparticle (LNP) mRNA, drug screening, and ultimately clinical supply of mRNA. Together, we will create the most integrated solution for mRNA vaccines and therapeutic R&D. Vernal will become the only one-stop-shop for our clients’ and partners’ mRNA needs, from concept all the way to clinical trials. The mRNA research associate or scientist will develop methods to synthesize, purify, and scale up mRNA. As a startup, we are seeking adaptable, creative thinkers who can independently foresee gaps and opportunities and who take the initiative to solve problems with a sense of urgency. We expect the work to be rewarding, fast-paced, and to offer ample opportunities to plan and create new solutions to help grow our business. Vernal will pay a competitive salary with generous benefits including health, dental, and vision insurance. Although hiring level will depend on experience, we expect to grow with our employees and are interested in a variety of backgrounds.
Vernal Biosciences is located in Colchester, Vermont, adjacent to Burlington which is home of the University of Vermont and the UVM Medical Center. Check out https://www.helloburlingtonvt.com/ for more information. The Burlington area, set on the shores of Lake Champlain, features the best of two worlds:
- Multicultural hub with great schools, restaurants, breweries, shopping, arts, and an affordable cost of living
- Gateway to the Green Mountains including world class hiking, camping, bicycling, and alpine and Nordic skiing