Benefits of Partnering with a US-Based CDMO

The mRNA Monthly—May 2024 Newsletter

From the FounderWelcome to the NEW monthly mRNA newsletter! In this monthly update, we will share the latest breakthroughs, insights, and innovations in mRNA and mRNA-LNP technology. By reading these updates, you will gain a competitive edge, stay ahead of…

Methods for mRNA poly(A) Sizing

mRNA poly(A) Sizing Methods

Poster Abstract: The mRNA Poly(A) Sizing Methods poster shows the poly (A) tail region of an mRNA functions to stabilize the mRNA and enable translation of the protein. Due to its biological importance of an mRNA’s poly(A) tail, the length…

Doggybone™ DNA for In Vitro Transcription

Poster Abstract: Linear DNA is used as the template to in vitro transcribe (IVT) synthetic mRNA. Common sources for templates are pDNA linearized with a restriction enzyme and PCR amplicons. Enzymatically produced Doggybone™ DNA (dbDNA), is a novel IVT template…

mRNA Capping Technologies

mRNA Capping Technologies

Poster Abstract: Synthetic mRNA is more potent, stable, and immuno-silent when the 5’ end contains a Cap1 structure (N7-methyl guanosine connected to the 5′ nucleotide through a 5′ to 5′ triphosphate linkage; N1 nucleotide methylated at the 2’ position). Cap1…

Poly(A) Tails ​For mRNA Synthesis

Poster Abstract: Poly-adenosine (poly(A)) tails are essential for the translation and stability of mRNA. Most mRNA synthesis processes rely on in vitro transcription(IVT) of mRNA from a linearized plasmid DNA (pDNA) template which includes a region of uninterrupted A-T base…

CRISPR/Cas9 RNA-DNA complex

Cas9 mRNA: Gene Editing Advantages

CRISPR-Cas9 RNA-DNA complex. Structure of Cas9 endonuclease (yellow-orange) complexed with a guide RNA (blue), a target DNA (pink) and a non-target DNA (green).  The revolutionary CRISPR-Cas gene editing technology has unlocked unprecedented possibilities in genome engineering, gene therapy, and cell…

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Vernal Biosciences Announces Partnership with REPROCELL

Vernal is excited to announce its new partnership with REPROCELL, furthering our mission to democratize access to mRNA, a life-changing technology, around the world. REPROCELL is a trusted leader in iPSC reprograming technologies and GMP iPSC manufacturing based in Japan. Together with REPROCELL, we…

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Vernal featured on Businesswire

Find our latest article on Businesswire here: Vermont-based CDMO, Vernal Biosciences Announces an Additional $20MM in Funding to Expand GMP mRNA and LNP Manufacturing Click the orange “Contact Us” button in the top right hand corner to find out more!